Increased challenges in health care (ageing populations, chronic disease, spiralling costs, etc.) urgently call for the development and exploitation of less conventional, non-carbon-based bioactive molecules that meet the biomedical requirements of the time ahead of us.

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Since reactive oxygen and nitrogen species (ROS and RNS), as well as sulfur containing low-molecular weight species play major roles in the pathogenesis of inflammation and nociception, we propose the development of redox-active metal complexes and small sulfur containing species that are capable to inactivate or modify ROS/RNS for the patient benefit: (a) as pharmacological tools for analyzing the function of ROS/RNS in (patho)physiological processes and (b) as new low-cost inorganic candidates for the treatment of chronic inflammatory diseases in an ageing population. Inorganic chemists, biochemists, and physical chemists, as well as medical/clinical experts of FAU are working together (coordinated by the Chair of Bioinorganic Chemistry) within this unique interdisciplinary research platform.

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• Manganese, Iron and Zinc based enzyme mimetics

• Bioinorganic Chemistry of H2S, Nitrogen species and their crosstalk

• Chemistry of Oxidative Stress